Amplification of the chromosomal region 9p24.1, which contains genes coding PD-L1 (CD274), PD-L2 (PDCD1LG2), and JAK2 (JAK2), has been linked to the overexpression of PD-L1 in cancer.[30] The current investigation reports that 3 patients carried CD274 and PDCD1LG2 amplifications without other driver mutations, and all 3 expressed high PD-L1 levels. The gene discussed is CD274; the disease is cancer.