In this study, the median TMB of the high-positive, low-positive, and negative PD-L1 expression subgroups was 8.1/MB, 6.7/MB, and 5.6/MB, respectively (Fig. S4, Supplemental Content, http://links.lww.com/MD/L193, which demonstrates TMB across PD-L1 expression in tumor). This evidence concerns the gene CD274 and neoplasm.