Clinical studie have found that SML injection can regulate the levels of urine and serum-related factors in DKD patients, improve the reabsorption rate of renal tubules to albumin, and effectively promote the improvement of renal tubule function and renal interstitial fibrosis.[18,55] Some scholars based on the experiment of DKD rat model found that blood urea nitrogen (BUN), 24-h urine proteinuria (24h-UTP) and serum creatinine (SCr) levels in the Salvia miltiorrhiza treatment group were significantly reduced compared with the control group. The gene discussed is ALB; the disease is diabetic kidney disease.