GHRL and gastroesophageal reflux disease: Hyangsayukgunja-tang showed increased mRNA expression levels of ghrelin and GOAT in rats,[31] and mildly, but significantly, lowered the severity score of GERD in a RCT.[32]Gaewool-Whadam-Jian used for GERD, was found to show positive effects in rat experiments.[33] The administration of Gaewool-Whadam-Jian improved the transport capacity of the small intestine, suggesting its potential to enhance gastrointestinal function, and it was observed that the intake of Gaewool-Whadam-Jian did not cause significant damage to kidney and liver tissues, indicating its relative safety profile.