AREG and lung carcinoma: overexpression of AREG has also been associated with mucinous lung cancer, as inhibition of AREG, as well as the anti-insulin growth factor-1 receptor, using siRNAs has been shown to sensitize cells to gefitinib-induced apoptosis, with a superimposed effect,[50] and all of the above studies suggest that AREG is involved in closely related to lung cancer tumourigenesis, which may provide a broad perspective for clinical application.