TG and hyperthyroidism: Therapeutic plasma exchange (TPE) is a blood purification method that can immediately remove harmful plasma constituents and has been reported to successfully treat severe cholestatic jaundice induced by MMI.[3] TPE can also remove a large number of serum protein-bound thyroid hormones and has been used as one of the effective alternative therapies in severe hyperthyroidism since the 1970s.[4] Thus, TPE may provide an alternative treatment for hyperthyroidism with severe drug-induced liver injury.