In our study, we found that the A allele of CCL5 − 403G/A in the allelic model, the AG genotype of CCL5 − 403G/A in the heterozygous model, the AA + AG genotype of CCL5 − 403G/A in the dominant model, the G allele of CCL5 − 28C/G in the allelic model, and the GG + GC genotype of CCL5 − 28C/G in the dominant model were significantly associated with an increased risk of AD. The gene discussed is CCL5; the disease is Alzheimer disease.