The allelic model (G vs C: OR = 1.46, 95% CI = 1.07–1.98, P < .01) and dominant model (GG + GC vs CC: OR = 1.74, 95% CI = 1.23–2.47, P < .001) of the CCL5 − 28C/G polymorphism were also associated with an increased risk of AD. This evidence concerns the gene CCL5 and Alzheimer disease.