More recent studies have proposed that LGI3 may participate in the cytokine network in various cancers[14,16,17] and that the expression levels of LGI3 could have potentially prognostic roles in brain, lung, and colorectal cancers.[16–18] In this study, integrative analyses of gene expression, gene product networks, and patient cohorts were employed to present evidence for the potential prognostic role of LGI3 in pancreatic adenocarcinoma (PAC). Here, LGI3 is linked to colorectal cancer.