Functional enrichment and GCN analyses for the LGI3-regulated genes that were altered in NSCLC indicated their involvement in similar GO categories.[18] By contrast, LGI3-regulated gene products that were altered in glioma cases were predominantly associated with hypoxia, cell proliferation, angiogenesis, p53, and HIF-1 pathways.[17] Therefore, these results show that LGI3-regulated gene products may play pathological roles in PAC and other cancers through overlapping and distinctive mechanisms. This evidence concerns the gene TP53 and central nervous system cancer.