The LGI family genes (LGI1, 2, 3, 4) are expressed in various tumor cells and their expression is not correlated with the normal cell origins.[35] The first gene member, LGI1, was proposed to be a tumor suppressor in brain tumors.[35,36] Expression levels and genetic variations of LGI3 were postulated to have prognostic value in brain, colorectal, and lung cancer.[16–18] The association of low expression levels of LGI3 with a negative prognosis of glioma and NSCLC[17,18] suggested that dysregulated expression of LGI3 may affect the cytokine network in cancer progression.[14,16]. This evidence concerns the gene LGI3 and central nervous system cancer.