CD4 and neoplasm: Furthermore, LGI3 expression and its negative correlation with infiltration of tumor immune suppressor cells and its positive correlation with infiltration of tumor immune promoters or modulators (macrophages, monocytes, mDC, CD4 + T cells, CD8 + T cells, natural killer cells and memory B cells)[54] (Fig. 8) suggested that LGI3 is a tumor-suppressing cytokine that regulates immune cell infiltration in PAC microenvironment.