Involvement in tumor metastasis was postulated for AHSG in head and neck squamous cell carcinoma,[56] CCL11 and CXCL13 in lung cancer,[57,58] GAS6 in PAC,[59] and TNFSF13B in glioma[60] Therefore, the dysregulation of LGI3 in PAC may affect PAC metastasis through intercellular communication in the tumor microenvironment. The gene discussed is LGI3; the disease is head and neck squamous cell carcinoma.