Conversely, 13 genes (ADIPOQ, C5, CFD, CRYAB, CYP39A1, DLK1, EGF, FABP4, IGFBP2, KLK3, RARRES2, REG3G, and RYR2) that were shown to be downregulated by LGI3 may be increased in PAC, again because LGI3 is downregulated in PAC (Fig. 2A, #). The gene discussed is KLK3; the disease is gonorrhea.