Thirteen gene products were found to be metastasis-specific, PAC-altered, LGI3-regulated genes (AHSG, BLNK, CALM1, CASP1, CBL, CCL11, CXCL13, F12, GAS6, KIT, NEUROG3, PTGS1, TNFSF13B; Figure 4B, gray nodes) in that these genes were not significantly altered in the primary tumor compared with healthy tissue. This evidence concerns the gene PTGS1 and neoplasm.