Previous studies reported that various gene products were regulated by LGI3.[1–5,10–15] Most LGI3-regulated gene products (169 out of 177) were also found to form a protein-protein interaction network cluster.[15] Fifteen genes (CD68, CD80, CTNNB1, CXCL5, CYBB, ERBB2, ERBB3, F3, IGFBP5, IL2RA, NCF2, PTGS2, PTK6, TIMP1, and TUBB3) that were reportedly upregulated by LGI3 may be decreased in PAC because LGI3 is already downregulated (Fig. 2A, *). The gene discussed is TIMP1; the disease is gonorrhea.