Conversely, 13 genes (ADIPOQ, C5, CFD, CRYAB, CYP39A1, DLK1, EGF, FABP4, IGFBP2, KLK3, RARRES2, REG3G, and RYR2) that were shown to be downregulated by LGI3 may be increased in PAC, again because LGI3 is downregulated in PAC (Fig. 2A, #). This evidence concerns the gene RYR2 and gonorrhea.