LGI3 and gonorrhea: The present study explored the potential prognostic value and functional network of LGI3 in PAC using integrative analysis of transcriptomics data and LGI3-regulated cytokine networks.[14,16] The significant reduction in LGI3 expression in PAC tissue (Fig. 1) suggested that the LGI3 signaling pathway may be perturbed in PAC carcinogenesis and progression.