PHB1 and infection: To date, several possiblehost receptors have been proposed, includingthe MXRA8 receptor (Figure 24B), prohibitin-1, TIM1, DC-SIGN, and the basigin CD147.219,220 The E2/prohibitin-1 interaction was inhibited by the small moleculedrug flavagline FL3, which binds prohibitin-1 with an IC50 of 22.4 nM (Figure 25).221 Despite the recognition of MXRA8as a host factor in CHIKV entry, its decrease in concentration orabsence did not fully stop the infection, suggesting the existenceof an MXRA8-independent entry pathway.222