Consistent with this idea, studies in both prion infected mice ablated for the NADase SARM1 [13] and in an in vitro cell model of prion neurotoxicity [43] are also supportive of the hypothesis that regulation of the NADH/NAD+ ratio helps to mitigate the damage caused by oxidative stress and slow prion disease progression [13]. Here, SARM1 is linked to prion disease.