In 2013, Sherren et al. [3] defined the effects of clotting changes caused by thermal injury in a retrospective review of acute burn-induced coagulopathy, using the criteria for coagulopathy of prothrombin time (PT) >14.6 s, activated partial thromboplastin time (aPTT) >45 s, or international normalized ratio (INR) >1.2; 39.3% of severely burned patients met their established criteria upon admission. This evidence concerns the gene F2 and blood coagulation disease.