For example, regarding genetic predisposition, the variation in the risk allele of the patatin-like phospholipase domain-containing protein 3 (PNPLA3), a gene that confers susceptibility for NAFLD, is more frequent in Hispanics (49%) followed by non-Hispanic Whites (23%), and Non-Hispanic Blacks (17%), which can account for the increased risk in the Hispanic population [57, 58]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.