LGR5 and hepatocellular carcinoma: Several liver CSC markers have been identified, including CD133, CD90, EpCAM, CD13, CD44, OV6, CD24, α2δ1, ICAM-1, Lgr5, and K19.15,16 Although the mechanisms remain unclear, an increasing number of studies have confirmed the link between liver CSCs and HCC metastasis.17,18 Understanding the role of liver CSCs in the development of HCC cell metastasis could provide new insights into the diagnosis and treatment of metastatic HCC.