NFE2L2 and Parkinson disease: Finally, a PD-related neuroinflammation model induced by lipopolysaccharide demonstrated that a pioglitazone treatment could improve the behavioral impairment in vivo, while increasing dopaminergic neuron survival within the SN through the activation of the Nrf2/HO-1 pathway and the inhibition of NF-kB signaling (Zakaria et al. 2019).