Based on this data, we propose an H-score threshold value of greater than 200 to consider ASPS, and more specific threshold value of greater than 300 that is more suggestive of TFE3-rearranged neoplasia such as ASPS (or TFE3-rearranged PEComa, or translocation-associated RCC) over other considerations such as melanoma, granular cell tumor, and other tested entities. The gene discussed is TFE3; the disease is granular cell tumor.