As conceptualized in Fig. 5, there is utility of quantitative TRIM63 RNA-ISH in combination with a practical panel of immunohistochemical stains (which would further help rule in or rule out melanoma or granular cell tumor); for example, robust expression of multiple melanocytic markers in the presence of only intermediate TRIM63 RNA-ISH expression would favor a diagnosis of melanoma. This evidence concerns the gene TRIM63 and granular cell tumor.