In the current study, the average TRIM63 RNA-ISH H-scores in PEComa were less than that of ASPS (228 and 330, respectively), but not statistically significantly so; subsets of PEComa and ASPS may exist on a spectrum of TFE3-related mesenchymal neoplasia that cannot always be fully delineated using current tools. Here, TFE3 is linked to neoplasm with perivascular epithelioid cell differentiation.