CYP19A1 and breast carcinoma: This has been confirmed in several clinical studies, a meta-analysis that included 30 studies revealed that aromatase inhibitor (AI)-treated patients with breast cancer had a 35% increase in osteoporotic fractures, an 18% increase in hip fractures, an 84% increase in vertebral fractures, and an 18% increase in non-vertebral fractures (Lee et al. 2020).