CYP2B6 and steatosis: Furthermore, the more robust transcriptional response (more genes responding), which includes enhanced induction of CYPs and other genes involved in circadian rhythms, lipid metabolism, and lipid transport, is associated with protection from steatosis observed in the hCYP2B6-Tg mice provided 1-PFOS in comparison to the Cyp2b-null mice provided 1-PFOS.