These genes belonged to several signaling pathways, such as the mitogen-activated protein kinase (MAPK), the Janus kinase signal transducer and activator of transcription (JAK-STAT), and T-helper 17 (Th17) pathways, which are also found to be enhanced in human pemphigus studies and could provide a novel target for future drug therapy. This evidence concerns the gene WNK2 and pemphigus.