Of the nine different cell types analyzed (Figure 2), CD45 cells (p < 0.0001), natural killer (NK)/CD56dim cells (p < 0.0001), T-cells (p < 0.005), neutrophils (p < 0.0001), dendritic cells (p < 0.0005), and CD8 T cells (p < 0.05) were significantly more abundant in canine PF diseased skin lesions compared to healthy controls. The gene discussed is CD8A; the disease is pemphigus foliaceus.