In the AMORIS study, a large multicenter investigation exploring the risk of stroke in relation to alterations in pro-atherogenic ApoB lipoprotein particles and anti-atherogenic ApoA1 molecules, elevated ApoB100 and reduced apoA1 levels were associated with a higher risk of stroke, and the Apo ratio emerged as a stronger predictor compared to the LDL-C/HDL-C and total cholesterol/HDL-C ratios [53]. The gene discussed is AOPEP; the disease is stroke disorder.