APOB and coronary artery disorder: In a meta-analysis comprising 12 case–control studies with 57,973 subjects, including 18,442 with early-onset CHD, the presence of an ApoB truncation was associated with a 72% reduction in coronary heart disease (odds ratio, 0.28; 95% confidence interval, 0.12–0.64; p = 0.002) [109].