NLRP3 and osteoarthritis: Furthermore, AS-IV has significant pharmacological effects, such as an anti-inflammatory effect on cartilage degeneration in patients with osteoarthritis [29], an antioxidant effect that inhibits the NLRP3/caspase-1 axis to inhibit NLRP3 inflammasome-mediated pyroptosis [30], and an immunomodulatory effect by regulating the T-cell receptor signaling pathway and Th17 cell differentiation [31].