2DG, 2-deoxy glucose, ASNA, adrenal sympathetic nerve activity; Ad, adrenaline; NAd, noradrenaline; AChR, acetylcholine receptor; ERK, extracellular signal regulated protein kinase; PKA, protein kinase A; PKC, protein kinase C; TH, tyrosine hydroxylase; DBH, dopamine β-hydroxylase; RH, single daily recurrent hypoglycaemia; 2RH, twice daily episodes of insulin-induced hypoglycaemia; PNMT, phenylethanolamine N-methyltransferase. Here, TH is linked to Hypoglycemia.