One of them, undertaking global gene profiling in the adrenal gland, reported a significant increase in the expression of several adrenal peptides including NPY, galanin, proenkephalin, and PP2A, a common phosphatase that can dephosphorylate TH and AADC [101,141] in response to recurrent insulin-induced hypoglycaemia [37]. Here, PENK is linked to Hypoglycemia.