For example, activated tumor necrosis factor (TNF) signaling in a tumor microenvironment (TME) may promote YTHDF2 expression, which consequently regulates NF-κB signaling to maintain intra-tumoral Treg survival by accelerating the degradation of m6A-modified transcripts that encode NF-κB-negative regulators [79]. The gene discussed is TNF; the disease is neoplasm.