Interaction of the NLRP3 inflammasome with ZIKV NS5 during replication has been shown to activate Caspase-1, leading to the production of IL-1beta, which plays a role in driving the acute inflammation during ZIKV infection [112,113], though others have reported that ZIKV NS3 downregulates the NLRP3 pathway in macrophages [114]. Here, NLRP3 is linked to Zika virus infectious disease.