Moreover, individuals with this immune profile had a 5% higher risk of ICU admission, even after controlling for potential confounders such as Legionella infection, viral load, CD4 count, and TB coinfection (crude RR 1.021 [CI 1.011–1.031] vs. adjusted RR 1.047 [CI 1.027–1.066]). Here, CD4 is linked to legionellosis.