Probably, the absence of IL-4 signaling, specifically in myeloid cells, plays a significant role in the expression of chemokine receptors needed for the recruitment of myeloid cells; IL-4 is necessary for both αvβ3 [35,36] and β5 integrins’ expression on immune cells, with this being of relevance for the establishment of myeloid cells at the site of infection [37]. The gene discussed is IL4; the disease is infection.