Our results may indicate that anergic IgD+IgM−CD27− B cells do not appear to play a significant role in autoimmunity associated with CVID, and further studies are needed to verify the participation of IgD+IgM− memory B cells in the immunopathogenesis of allergic rhinitis/allergic asthma in CVID patients. This evidence concerns the gene CD40LG and allergic rhinitis.