APEX1 and psoriasis: Similarly, to treat exacerbated psoriasis due to ROS overexpression, Lu et al. demonstrated the use of biomimetic iron single-atom catalysts (FeN4O2-SACs), which can mimic the activities of CAT, SOD, and ascorbate peroxidase (APX), effectively improving psoriasis-like symptoms in mice and preventing recurrence (Figure 6a,b) [137].