Although the APOE-ε4 represents the strongest genetic risk factors for AD [54], as genetic research has proceeded, studies have found suggestive links between late-onset AD and a number of other genes, such as ABCA7, CLU, CR1, PICALM, PDL3, TREMZ, and SORL1 [96,97], which might be relevant in influencing SN performances, too. This evidence concerns the gene PICALM and Alzheimer disease.