SMC3 and myeloid neoplasm: In addition, mutations in the CEBPA, RUNX1, CBFB, and NPM1 myeloid transcription factors, in the SF3B1, U2AF1, SRSF2, and ZRSR2 splicing machinery components, in the ASXL1, BCORL1, EZH2, DMNT3A, TET2, IDH1, and IDH2 epigenetic regulators, in the STAG2, SMC1A, SMC3, and RAD21 cohesion complex, and in the TP53, WT1, and PHF6 tumor suppressors are also commonly present in myeloid neoplasms [8,13,14,15].