Myeloid neoplasms are known to have chromosomal translocations that regulate PML-RARA, CBFB-MYH11, and RUNX1-RUNX1T1 myeloid transcription factors and JAK2, FLT3, KIT, and RAS, activating driver mutations in signaling pathways. The gene discussed is RUNX1; the disease is myeloid neoplasm.