However, DEK::NUP214, KMT2A (MLL), BCR::ABL, GATA2, MECOM (EVI1), monosomy 5 or deletion 5q, monosomy 7, monosomy 17/abn (17p), complex karyotype, and monosomal karyotype have negative effects on the course of AML disease [6]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.