The most common pathogenic gene variants in ALL patients are BRCA2 (Exon11 c.6468_6469delTC (11%) and Exon23 c.907delA (11%)) and KMT2C (Exon14 c.2468delTinsAC (11%) and Exon7 c.943G>A (11%)). This evidence concerns the gene BRCA2 and acute lymphoblastic leukemia.