A detailed investigation into the DDR pathways revealed a substantially higher mutation count in critical DDR pathways, including Base Excision Repair (BER), Fanconi Anemia (FA), Homologous Recombination Repair (HRR), Mismatch Repair (MMR), and Nucleotide Excision Repair (NER) in the MSKCC SPEN mutant cohort (p < 0.05). This evidence concerns the gene SPEN and Fanconi anemia.