CircKDM4C inhibits the expression of hsa-let-7b5p as a sponge in AML cell lines, resulting in the upregulation of p53, which is the target gene of hsa-let-7b-5p.The transcription of SLC7A11 is inhibited by p53, which promotes ferroptosis [124]. Here, TP53 is linked to acute myeloid leukemia.