For instance, a prior study in adult zebrafish demonstrated that chronic exposure to butyl-paraben (BuP), one of the parabens already shown to induce anxiety-like behavior in zebrafish larvae, results in circadian rhythm modulation and abnormal neurobehavioral responses to light stimulation; they later found that the explainable cause of this phenomenon is the ability of BuP to cross the blood–brain barrier and modulate the level of transcripts that are associated with phototransduction and the circadian rhythm [73,74]. Here, COMMD3 is linked to Anxiety.