Chymase inhibition improved cardiac remodeling in various animal models, including rapid ventricular pacing-induced heart failure in dogs [155], LAD-occlusion-induced myocardial infarction in rats [184] and hamsters [185], ischemia-reperfusion cardiac remodeling in pigs [186], and pressure overload-induced left ventricular remodeling in rats [148]. The gene discussed is CMA1; the disease is myocardial infarction.