Worldwide, several PLN variants have strong association with variable cardiac phenotypes ranging from dilated cardiomyopathy [8,17] to hypertrophic [9,10,11,12,13,18] and even arrhythmogenic cardiomyopathy (ACM) [20,21], but the causative defects leading to cardiomyopathies remain incompletely elucidated. The gene discussed is PLN; the disease is dilated cardiomyopathy.