It is also interesting to note that an inflamed lymph node biopsy from an AOSD patient revealed the dominance of CD8+ T cells, but only a small number of them expressed the maturity marker granzyme B [36] along with increased levels of Th2 cytokines, including IL-4 and IL-13 [30], which may also be related to an increased percentage of Tc2 cells at the systemic level. The gene discussed is CD8A; the disease is adult-onset Still disease.