Next, we analyzed the frequency of CCR6–CXCR3+ Tc1 within ‘naïve’, CM, EM, and TEMRA CD8+ T cells in patients with AOSD (Figure 4) and found that the level of Tc1 cells in ‘naïve’ and TEMRA CD8+ T cells was decreased if compared to healthy controls (69.01% (68.79; 78.10) vs. 82.54% (71.41; 87.36) with p = 0.015 for ‘naïve’ CD8+ T cells and 57.87% (43.47; 67.76) vs. 76.89% (69.22; 80.09) with p = 0.003 fro TEMRA CD8+ T cells, respectively). This evidence concerns the gene CXCR3 and adult-onset Still disease.