Next, compared with the healthy control, the percentages of CCR6–CXCR3– Tc2 cells in patients with AOSD were increased in ‘naïve’ EM and TEMRA CD8+ T cells (23.18% (15.82; 25.62) vs. 8.37% (6.82; 13.44) with p = 0.003, 20.25% (10.23; 30.89) vs. 8.18% (4.08; 11.82) with p = 0.022, and 39.43% (27.73; 54.96) vs. 19.32% (16.45; 26.65) with p = 0.003, respectively). This evidence concerns the gene CD8A and adult-onset Still disease.