So far, we have screened approximately 2500 phytochemicals including aspalathin, while other phytochemicals, for example, resveratrol [16] and taxifolin [17], have been found to stimulate GU in cultured L6 myotubes, and to activate the pathways of phosphatidylinositol 3-kinase (PI3K)-Akt (PKB: protein kinase B) and/or 5′-adenosine monophosphate-activated protein kinase (AMPK), hence promoting the translocation of glucose transporter 4 (GLUT4) to the plasma membrane of L6 myotubes under insulin absence and showing an antihyperglycemic effect in T2D model db/db, ob/ob, and KK-Ay/Ta mice [12]. This evidence concerns the gene INS and type 2 diabetes mellitus.