A recent retrospectively work evaluated NSCLC patients treated with ICI in any line and identified 14 gene expression profiles associated with post-ICI survival, namely IDO1, PD-L2, cytotoxicity, cytotoxic cells, IFN downstream, CTLA4, PD-L1, TIGIT, lymphoid, immunoproteasome, exhausted CD8, IFNγ, tumor inflammation signature and APM. This evidence concerns the gene TIGIT and neoplasm.