EGFR and non-small cell lung carcinoma: Based on the data and considerations presented above, in our opinion, adjuvant chemotherapy before osimertinib in patients with resected NSCLC harbouring EGFR mutations should be omitted in elderly patients (over 70 years) and in all patients with comorbidities that would increase the risk of death during chemotherapy or that would prevent physicians from the administration of optimal cisplatin-based chemotherapy.