Given that anti-dsDNA and ANA autoantibodies are highly associated with lupus [11,12,18,19,20,21,22,23,24], and can even be predictive of disease activity in SLE/LN [44,45,46,47,48,49,50,51,55], it is important to engineer POC approaches to make this feasible. The gene discussed is BTG3; the disease is systemic lupus erythematosus.