IDH1 and glioblastoma: Additionally, in the intricate glioblastoma genomic pattern, it is also quite common to see overexpression of epidermal growth factor receptor (EGFR), mutations of isocitrate dehydrogenase 1 (IDH1) and phosphate and tensin homolog (PTEN) [41], which when altered largely contribute to uncontrolled growth, invasiveness and the ability to escape different checkpoints characteristic of glioblastoma.