The stimulation/activation of sGC was also shown to significantly inhibit the myofibroblastic differentiation of human prostatic and dermal fibroblasts, as well as to blunt myofibroblast-like features of endothelial cells harvested from fibrotic skin lesions of patients with systemic sclerosis [27,33,35,36]. Here, SGCB is linked to systemic sclerosis.