MYC and glioblastoma: In line with this idea, using orthotopic GBM tumors in mice, it has been shown that engineered exosomes from human bone marrow mesenchymal stem cells (MSCs) encapsulating siRNAs targeting Myc (iExo-Myc) inhibit proliferation and angiogenesis, revert PMT, suppresses tumor growth, and extends survival [102].