Moreover, by recruiting corepressors (CoRs) and HDACs that in turn recruit enhancer of zeste homolog 2 (EZH2) to modify histones with repressive H3K27me3 marks, ERα may direct DNA methylation-mediated silencing of a subpopulation of basal, stem, and EMT genes that potentially enforce luminal differentiation of BC cells [13]. The gene discussed is EZH2; the disease is breast cancer.