It was soon discovered that caspase-3 cleaves GSDME (also known as DFNA5 (deafness, autosomal dominant 5)) and this results in GSDME N-terminal pore formation and pyroptosis, expanding the mechanism by which pyroptosis can be induced beyond caspase-1-mediated cell death [31,32]. The gene discussed is GSDME; the disease is autosomal dominant nonsyndromic hearing loss.