ICAM3 and cancer: Activation of PI3K/Akt leading to inhibition of apoptosis has also been described for ICAM-2 and ICAM-3 in the protection of T cells and B cells against TNF-α and Fas-mediated cell death and in the enhancement of cancer cell survival, migration and invasion [171,172,173], which has been proposed to be dependent on their binding to activated ERM proteins.