ICAM-3 is constitutively expressed on all leukocytes and can be particularly present on some endothelial and tumour cells (e.g., 133+ non-adherent endothelial-forming cells and lymphomas) [32,105] and regulated at the transcriptional level by the transcription factor RUNX3 during the transendothelial migration of monocytes and their differentiation to macrophages [106]. The gene discussed is ICAM3; the disease is neoplasm.