ICAM1 and multiple sclerosis: In this regard, it has been reported that ICAM-1 but not ICAM-2 is required for the activation, proliferation and differentiation of naïve CD4+ T-cells stimulated with myelin-derived peptides presented by splenic DCs in a mouse model of experimental autoimmune encephalitis (EAE) [157], an animal model of multiple sclerosis whose pathogenesis is dependent on Th1 and Th17 effector functions.