TPPP and synucleinopathy: Focusing on synucleinopathies, these ideas include the Sherpa hypothesis which proposes that Phenotype-Preserving Disordered Proteins (PPDPs), such as TPPP and SYN, and oligomeric structures as well as the homo- and hetero-associations of these disordered proteins can generate distinct, physiologically/pathologically appropriate phenotypes [106].