Immune checkpoints exist in a variety of molecules expressed by immune and tumor cells, with a role in acquired immune response inhibition or activation, such as cytotoxic T lymphocyte-associated molecule 4 (CTLA-4), programmed cell death ligand 1 (PD-L1), and programmed cell death receptor 1 (PD-1) [4]. This evidence concerns the gene CD274 and neoplasm.