TDSFs, such as the vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNF-α), transforming growth factor-β (TGF-β), and interleukins (ILs), such as IL-6 and IL-10, can derive from tumor cells, which are themselves induced by the local inflammatory microenvironment. The gene discussed is IL6; the disease is neoplasm.