For instance, while Cx43 was reported to have a role in resistance of glioblastoma (GBM) cells to temozolomide (TMZ) thanks to an anti-apoptotic effect [302], when combined with a Cx43 inhibitor, responsiveness to TMZ is improved by inhibiting AKT signaling and inducing both autophagy and apoptosis [310]. The gene discussed is GJA1; the disease is glioblastoma.