We observed that DOX-exposed CC10-IL-13 mice developed more force in esophageal muscle contraction in response to the cumulative additions of carbachol compared to C-kit-neutralized ΔdblGATA/CC-10-IL-13 (both eosinophil- and mast cell-deficient) mouse models of EoE, the latter of which showed significantly reduced force in contraction of esophageal muscles. The gene discussed is KIT; the disease is eosinophilic esophagitis.