In this report, we demonstrate that VIP and VIP receptors are induced in human EoE, VIP has chemoattractant activity for eosinophils similar to that of eotaxin 3, and the signaling of VIP in humans is linked to the CRTH2 receptor on eosinophils and CRTH2 and the VPAC-2 receptor on mast cells. This evidence concerns the gene PTGDR2 and eosinophilic esophagitis.