IFNG and Bartsocas-Papas syndrome 1: However, the immune system has been linked to the pathogenesis of MRONJ as BPs cause immune dysregulation that leads to the expression of pro-inflammatory molecules; they increase the production of IFN-γ, suppress the differentiation of dendritic cells, and increase the chemotaxis, phagocytosis, and oxidative stress of neutrophil granulocytes [30].