Six genes are known to be involved in the causation of WS: PAX3 (paired box 3), MITF (melanocyte inducing transcription factor), SOX10 (SRY-Box transcription factor 10), EDN3 (endothelin 3), EDNRB (endothelin receptor type B) and KITLG (KIT ligand). The gene discussed is MITF; the disease is Werner syndrome.