Cerebrospinal fluid analysis (CSF) of PCD patients can show both aspecific inflammatory changes in the early stages, such as primarily elevated protein, lymphocytic pleocytosis, and oligoclonal bands [80], and more specific findings such as 14-3-3 protein, specific for Creuzfield–Jacob diseases, thus leading to a wrong diagnosis, especially if one does not have instrumental findings suggesting the presence of a tumour [102]. This evidence concerns the gene YWHAQ and neoplasm.